Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Exposure can take place through ingestion or topical exposure. Hellmann K, Knoppe T, Radeloff I, Heine J (2003) The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. Advantage Multi® has late-dose forgiveness, so your dog’s heart is protected even when you’re a few days late*. Toxic Dose This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. They’re potentially deadly for your dog. 6 The animal should be standing for easy application. The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v)/moxidectin (2.5% w/v) combination (Advocate Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs. Dogs over 25kg Apply by dividing the dose between the shoulder blades, on the midline of the back between the hips, and at one point in between. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. Company: Bayer Animal Health for dogs. The active ingredients in Advantage Multi for Dogs are Imidacloprid and Moxidectin. Dogs were blocked according to gender and body weight on test day -1. How is moxidectin given? Do not apply this medication to irritated skin. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Do not bathe your pet for at least 4 days after its application. Imidacloprid, the medication paired with topical moxidectin, begins to kill fleas within 4 hours. Advocate treats and protects against the major parasit Advocate treats and protects against the major parasit Advantage Multi® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Six dogs were treated with melarsomine (Immiticide®, Merial) (2.5 mg/kg) at enrollment, followed one month later by two injections 24 h apart. Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). Moxidectin is safe for dogs in the correct dosage, but it can have significant side-effects. In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. Quest Plus gel for horses contains 20 mg/mL (2%) plus 125 mg praziquantel (12.5%). How is Advocate used? During the first 30 minutes after application, monitor to ensure that your dog does not lick the product. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Remove any collar prior to application and replace when product is dry. Three studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis strains. ADVOCATE for DOGS and CATS - SPOT-ON against FLEAS, MITES, HEARTWORMS and ROUNDWORMS - BAYER - imidacloprid + moxidectin - neonicotinoid + macrocyclic lactone Brand: ADVOCATE ® Company: BAYER. Heartworms are not just gross. Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin? Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. 17. Dogs under 25kg Apply between the shoulder blades. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. Advantage Multi for Dogs is not for human use, and should always be kept out of the reach of children. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. 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